Content Delivery Networks (CDNs) optimize web performance by handling static and dynamic content differently. Static content, such as images and CSS files, remains unchanged and is efficiently stored in edge servers worldwide, reducing latency and server load through methods like Cache-Control headers and compression. Dynamic content, like personalized dashboards or API responses, changes frequently and uses techniques like dynamic content acceleration, edge computing, and partial caching. Best practices for static content include long-term caching, HTTP/2 and HTTP/3, and smart global delivery. For dynamic content, focus on edge caching with short TTLs, reducing payload size, and smart routing. Real-world examples show how CDNs benefit media streaming by caching videos and help e-commerce with personalized recommendations and fast page loads. Proper CDN strategies improve speed, reduce costs, and enhance user experience.